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制药 - 细胞

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MP-SPR for living cells

There are many drivers behind cell-based research including tissue engineering, in vitro toxicology, drug delivery, but also antibacterial coatings.

Surface plasmon resonance has been originally commercialized for protein interaction measurements. It is only recently that researchers started developing the SPR for measurements on living cells. We are proud to be the first ones to enable measurements of trans- and paracellular uptake. 

  • BioNavis together with University of Helsinki is pioneering the measurements of drug- and nanoparticle-cell interactions
  • Many of our users are using MP-SPR to measure cell spreading or cell attachment on different biomaterials and coatings
  • MP-SPR can also be used as a biosensor in detection of cell-specific metabolites to confirm cell differentiation and/or cell functionality
  • Similarly, a few groups are working on biofilm formation or antibacterial coatings


See five reasons to choose MP-SPR for living cells:

  • Able to measure living cell and bacteria attachment in real-time
  • Able to separate permeation from internalization label-free
  • Surface freedom
  • Control of temperature and shear-stress
  • Combination of MP-SPR with electrochemistry

See five key questions about living cells that MP-SPR can answer:

  • What is drug absorption route of this pharmaceutical?
  • Which nanoparticle is the best one for drug delivery?
  • How does a nanoparticle or virus enter the cell?
  • What is the kinetics of cell attachment to a surface? 
  • Which surface is the most resistant to bacterial growth?

Selected publications:

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